Seizures and steroids.

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Seizures and steroids.

Annotations Seizures and steroids For over 40 years we have known that some children with otherwise intractable fits improve with steroids, ' and for over 30 years that a similar response may be obtained with adrenocortico-trophic hormone.2 Since that time a considerable amount of work has centred on infantile spasms, particularly on the relative efficacies of prednisone and adrenocorticotrophi...

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Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.

Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy group in the alpha-position and 5-H in the alpha- or ...

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Sports supplements and Anabolic Androgenic Steroids

Recently, the use of sport supplements has become so common among most athletes. These supplements may contain undeclared substances that are banned by such international authorities as WHO, IOC and WADA. The present study, thus, is aimed at examining the final sport supplement products in terms of banned substances and measuring the adulteration level in order to prove the safety of these prod...

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Action of two neuroactive steroids against motor seizures induced by pentetrazol in rats during ontogeny.

The anticonvulsant action of two neuroactive steroids, 3alpha-hydroxy-5beta-pregnan-20-one (pregnanolone) and triethylammonium 3 alpha-hydroxy-20-oxo-5 alpha-pregnan-21-yl hydrogensuccinate (THDOC-conjugate), was tested against motor seizures induced by pentetrazol in immature rats. Five age groups (7, 12, 18 and 25 days old and adult rats) were pretreated with the steroids in doses from 2.5 to...

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Differential, Delayed and Dual Seizures-“3D Seizures”

Since historical times, hysteria has colored the literature from novels to movies. The nomenclature changed from hysteria to dissociation over time. With More reliable diagnostic tools being available it became easier to objectively identify this phenomenon. However clinical examination still appears to be the sole diagnostic approach due to ambiguity in results of widely used investigations li...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1985

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.60.2.94